Certificate of Analysis
Independent laboratory testing confirms purity and composition of this research compound.
ENDO PASSED
Compound Specifications
| Form | Lyophilized powder |
| Vial size | 4mg |
| Kit size | 10 vials per kit |
| Purity | ≥99% (HPLC verified) |
| Mass confirmation | ESI-MS confirmed |
| Heavy metals | <10 ppm (ICP-MS) |
| Endotoxin | <1.0 EU/mg (LAL) |
| Residual moisture | <5.0% (Karl Fischer) |
| Storage — lyophilized | −20°C, protected from light |
| Lyophilized stability | 24 months from manufacture |
| Reconstitution | Bacteriostatic water for injection |
| Storage — reconstituted | 4°C, use within 28 days |
| Packaging | Sterile glass vial · rubber stopper · aluminium crimp cap |
Mechanism of Action
KPV (Lys-Pro-Val) is a tripeptide representing the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH). It is the minimal active fragment of α-MSH responsible for its anti-inflammatory properties, and it acts through melanocortin-1 receptor (MC1R) signalling to suppress NF-κB activation — the master regulator of inflammatory cytokine production. KPV demonstrates significant potency in inflammatory models despite its small size, and unlike full-length α-MSH, it does not carry tanning/pigmentation activity (which requires the N-terminal tripeptide His-Phe-Arg-Trp).
A particularly noted property of KPV is its ability to penetrate intestinal epithelial cells and interact with intracellular receptors, making it relevant to gut barrier and inflammatory bowel research. It can directly modulate immune cells in the lamina propria, independent of luminal MC1R signalling.
Research Overview
| Model | Finding |
|---|---|
| Mouse colitis (DSS-induced) | KPV significantly reduced colon inflammation scores, maintained crypt architecture, and lowered TNF-α and IL-6 levels |
| Human intestinal epithelial cells | Confirmed transcellular transport of KPV across epithelial monolayers; intracellular NF-κB suppression demonstrated |
| Mouse sepsis model | KPV reduced circulating inflammatory cytokines and improved survival rates vs. controls |
| Wound healing (mouse) | Anti-inflammatory and pro-healing effects in cutaneous wound models with MC1R-expressing cells |
Research Notes
KPV’s combination of gut epithelial penetration and potent anti-inflammatory activity makes it one of the more interesting peptides in gastrointestinal inflammatory research. Its small size (tripeptide) is unusual for a compound with this level of biological activity — most tripeptides are too small to engage receptors with high affinity. The MC1R mechanism is well validated. Research is ongoing in IBD models, and KPV is increasingly studied in nanomedicine formulations designed to deliver it specifically to inflamed intestinal tissue.
Frequently Asked Questions
What is alpha-MSH?
Alpha-melanocyte-stimulating hormone is an endogenous peptide derived from POMC (pro-opiomelanocortin). KPV is the C-terminal tripeptide of α-MSH and retains its anti-inflammatory properties without the pigmentation activity of the full molecule.
How does KPV interact with the gut?
KPV can be transported across intestinal epithelial cells via peptide transporters, allowing it to reach immune cells in the intestinal wall directly and suppress intracellular NF-κB signalling.
How should the vial be stored?
−20°C lyophilized. Reconstituted: 4°C, use within 28 days.
Is this for human use?
No. Research use only.
What is KPV used for in research?
KPV is studied for its anti-inflammatory signalling via MC1R-mediated NF-κB suppression, with particular focus on intestinal epithelial biology and gut inflammation models. Rodent studies of DSS-induced colitis have demonstrated reduced inflammatory markers, maintained crypt architecture, and improved tissue histology. It is also examined for transcellular transport across gut epithelium, making it relevant to mucosal immunology research.
Is KPV available as lyophilized vials?
Yes. BIOHACKER’s KPV is supplied as lyophilized powder in individual vials. Each vial contains 4mg of research-grade KPV at ≥99% HPLC purity. Reconstitute with bacteriostatic water before use. For research purposes only.
What purity is BIOHACKER’s KPV?
≥99% by HPLC, with ESI-MS mass confirmation and endotoxin testing to USP <85> standards. Full Certificate of Analysis is available on the COA page and traceable by batch number.
Is this for human consumption?
No. KPV from BIOHACKER is sold strictly for in vitro research and laboratory use. It is not intended for human or veterinary use and is not a dietary supplement or pharmaceutical product.
Ready to order? Add to Cart — $35
Research Use Only. This product is intended for in-vitro laboratory research purposes only. Not for human consumption, clinical use, veterinary use, or food/drug manufacturing. Not evaluated or approved by the FDA or any regulatory authority. Handle with appropriate laboratory precautions. Keep out of reach of children.
Reviews
There are no reviews yet.