Certificate of Analysis
Independent laboratory testing confirms purity and composition of this research compound.
ENDO PASSED
Stack Rationale
The Aesthetics Stack targets three distinct dimensions of skin and body composition biology: dermal extracellular matrix remodelling (GHK-Cu), melanogenesis and UV-response regulation (Melanotan-2), and adipocyte lipid mobilisation with structural preservation (AOD-9604). Together they provide a multi-pathway tool kit for researchers studying the cellular and endocrine determinants of skin quality and body composition at the tissue and systems level.
What’s Included
| Compound | Vial dose | Qty | Mechanism |
| GHK-Cu (Copper Tripeptide) | 100 mg | 1 vial | ECM remodelling, collagen synthesis, antioxidant |
| Melanotan-2 | 10 mg | 1 vial | MC1R/MC4R agonist — melanogenesis, photoprotection |
| AOD-9604 | 10 mg | 1 vial | GH C-terminal fragment — lipolysis, lipid regulation |
| Form | Lyophilized powder (all vials) |
| Purity | ≥99% (HPLC verified, per vial) |
| Mass confirmation | ESI-MS confirmed (per vial) |
| Heavy metals | <10 ppm (ICP-MS) |
| Endotoxin | <1.0 EU/mg (LAL) |
| Residual moisture | <5.0% (Karl Fischer) |
| Storage — lyophilized | −20°C, protected from light |
| Lyophilized stability | 24 months from manufacture |
| Reconstitution | Bacteriostatic water for injection (per compound) |
| Storage — reconstituted | 4°C, use within 28 days |
| Packaging | Sterile glass vials · rubber stoppers · aluminium crimp caps |
Mechanism Breakdown
| Compound | Primary mechanism | Key research endpoint |
| GHK-Cu | Promotes collagen I/III/IV synthesis; activates MMP-1/2 for ECM remodelling; antioxidant via SOD/catalase upregulation | Dermal thickness, fibroblast activity, wound closure rate |
| Melanotan-2 | Agonises melanocortin receptors (MC1R = melanogenesis; MC4R = appetite/energy); triggers eumelanin shift in melanocytes | Melanin content, photoprotective pigmentation, MC receptor binding kinetics |
| AOD-9604 | Mimics lipolytic domain of GH (hGH 176-191); activates adipocyte beta-3 AR signalling; no IGF-1 axis perturbation | Adipocyte lipolysis rate, fat depot volume (visceral/subcutaneous), lipogenesis markers |
Research Notes
GHK-Cu’s mechanism is particularly well-documented: the copper-chelating tripeptide upregulates collagen synthesis in fibroblast culture, downregulates MMP inhibitors to remodel aged ECM, and increases glycosaminoglycan production — all relevant endpoints for dermal quality research. At the concentration range supplied (high-dose 100 mg vial), dilution factors for in vitro assays typically put working concentrations in the 1–100 µM range. Melanotan-2’s MC1R agonism in melanocyte culture produces measurable increases in melanin output within 48–72 hours in standard assay conditions. AOD-9604’s selective lipolytic activity without IGF-1 perturbation makes it a useful tool for isolating GH’s fat metabolism signal from its anabolic growth effects in comparative studies.
Frequently Asked Questions
- Why is GHK-Cu supplied at 100 mg in this stack?
- GHK-Cu is a small tripeptide (MW 340 Da) used at relatively high concentrations in tissue culture models. The 100 mg vial provides a generous stock for serial dilution across multiple experiments. In vitro effective concentrations typically range from 1–100 µM; in vivo animal model protocols often use 1–10 mg/kg dosing ranges.
- Does Melanotan-2 only affect pigmentation in research models?
- No. MT-2 is a non-selective melanocortin agonist — it engages MC1R (melanogenesis), MC3R (energy metabolism), MC4R (appetite, sexual arousal circuitry), and MC5R (exocrine function). Researchers studying MC receptor pharmacology use MT-2 as a reference pan-agonist, then use selective agonists/antagonists to dissect receptor-specific contributions.
- How does AOD-9604 differ from full-sequence growth hormone in adipose research?
- Full GH activates both lipolytic and anabolic (IGF-1-mediated) pathways. AOD-9604 (hGH residues 176–191) retains the lipolytic activity of GH — acting via beta-3 adrenergic receptor signalling in adipocytes — without activating the IGF-1 axis. This makes it a useful tool for isolating the fat metabolism component of GH biology in mechanistic studies.
What compounds are in the The Aesthetics Stack?
The The Aesthetics Stack includes: GHK-Cu (100 mg × 1), Melanotan-2 (10 mg × 1), and AOD-9604 (10 mg × 1). This stack targets three dimensions of skin and body composition biology: GHK-Cu for dermal ECM remodelling, Melanotan-2 for melanogenesis and UV-response regulation, and AOD-9604 for adipocyte lipid mobilisation. It provides a multi-pathway tool kit for researchers studying skin quality and body composition at the tissue and systems level.
Are the The Aesthetics Stack vials pre-mixed or individual?
Yes — each compound ships as a separate, individually labelled lyophilized vial. They are not pre-mixed. Each vial is labelled with compound name, dose, batch number, and storage instructions to ensure clear identification throughout the research workflow.
What purity are the compounds in the The Aesthetics Stack?
All compounds are ≥99% by HPLC, with ESI-MS mass confirmation and endotoxin testing to USP <85> standards. Full Certificate of Analysis documentation is available on the COA page and traceable by batch number for each compound.
Is this for human consumption?
No. The The Aesthetics Stack from BIOHACKER is sold strictly for in vitro research and laboratory use. It is not intended for human or veterinary use and is not a dietary supplement or pharmaceutical product.
Ready to order? Add to Cart — $285
Research Use Only. This product is intended for in-vitro laboratory research purposes only. Not for human consumption, clinical use, veterinary use, or food/drug manufacturing. Not evaluated or approved by the FDA or any regulatory authority. Handle with appropriate laboratory precautions. Keep out of reach of children.
Reviews
There are no reviews yet.