The Khavinson Triple

Professor Vladimir Khavinson’s team at the St. Petersburg Institute of Bioregulation and Gerontology has produced some of the most extensive preclinical neuropeptide research in existence — spanning four decades and covering dozens of bioregulatory peptides. Semax, Selank, and Pinealon each originate from this lineage, and each hits a different node in the cognitive and neurological system.

Why these three compounds

Semax is a synthetic analogue of ACTH(4–10) that upregulates BDNF mRNA expression in the hippocampus — directly activating the gene for Brain-Derived Neurotrophic Factor. It is the primary cognitive performance and neuroprotection compound in the stack. Four minutes to cross the blood-brain barrier via nasal delivery. Twenty-four hour duration of action from a single dose. Forty years of Russian clinical use in stroke recovery and cognitive rehabilitation.

Selank is a synthetic tuftsin analogue with GABA-A receptor modulating activity. It produces anxiolytic effects without sedation, dependence, or tolerance, and has documented immunomodulatory properties. Its role in this stack is to reduce the stress-load interference that degrades cognitive performance — the signal Semax tries to amplify can be drowned out by high cortisol and sympathetic activation. Selank clears that interference.

Pinealon is a tripeptide (Glu-Asp-Arg) derived from the pineal gland, also from Khavinson’s group. Its primary documented effects are on neuropeptide signaling, circadian regulation, and neuroprotection. Pinealon shows activity in animal models of cognitive decline, neurodegeneration, and age-related brain changes — making it the longevity/neuroprotection layer of the triple, while Semax handles performance and Selank handles resilience.

This is not a casual nootropic stack — it is three compounds from the same research lineage, each addressing a distinct neuroscientific target, studied by the same team across decades.

Protocol reference

Research protocol: Semax 200–600mcg intranasal daily; Selank 250–500mcg intranasal as needed (or daily); Pinealon 5–10mg subcutaneous or intranasal, cycled (10 days on, 20 days off). Semax and Selank can be administered simultaneously. Pinealon is typically cycled rather than run continuously.

What’s included

• Semax — HPLC-verified ≥99% purity
• Selank — HPLC-verified ≥99% purity
• Pinealon — HPLC-verified ≥99% purity

For research use only. Not for human consumption. Not medical advice. COA available on every batch. HPLC-verified ≥99% purity on all compounds.